Baycrest

"CCNA intends to make Canada a leader in dementia prevention by creating an infrastructure and a master protocol that can be used to test combination interventions, both pharmacological and non- pharmacological." Moving the dial on dementia research Launched in 2014, CCNA's first phase included setting up one of the world's most in-depth studies into different forms of dementia and the largest dementia study in Canada, the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study. Through this study, extensive health data are being gathered from about 2,000 older adults with mild memory loss or various forms of dementia. This study aims to accelerate dementia research around the world by providing data that will contribute to a better understanding of Alzheimer's disease and other neurodegenerative disorders. During the first phase, CCNA established the necessary infrastructure to foster close collaborations among Canadian researchers. Through these partnerships, researchers created health promotion materials, such as the Brain Health Food Guide and Indigenous-specific factsheets on dementia. Researchers also discovered potential biomarkers in saliva that could lead to earlier detection of Alzheimer's disease. "CCNA is an innovative and powerful national collaborative hub for dementia research and knowledge translation," says Dr. Yves Joanette, former Scientific Director of the CIHR Institute of Aging. "Over the last five years, Dr. Chertkow and his colleagues have mobilized the dementia research community and created the environment and the shared platforms required to synergize research efforts in all the areas that will make the most impact in preventing, treating brain diseases causing dementia, and in best supporting those living with dementia and their caregivers. CIHR is pleased to be joined by many relevant partners in supporting Phase II of CCNA as they will be adding a critically important research program on dementia prevention." CCNA's scientific headquarters moves to Baycrest Baycrest is advancing CCNA's work through: • the involvement of researchers at Baycrest's Rotman Research Institute and Baycrest Hospital as leaders and members of various CCNA teams; • a partnership with the Baycrest- led Centre for Aging + Brain Health Innovation to accelerate the development and commercialization of technology stemming from CCNA researchers to support people with dementia and their caregivers; • Cogniciti, the Baycrest-developed, online, brain health assessment, which will enhance CCNA's recruitment efforts to encourage more individuals to participate in clinical trials to delay and prevent Alzheimer's disease; • the creation of the Kimel Family Centre for Brain Health and Wellness at Baycrest, a unique research and care facility focused on brain health, which will serve as a primary test location for CCNA's prevention program. 2018–2019 YEAR IN REVIEW 7

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