Baycrest

Led by Dr. Howard Chertkow, Baycrest's Anne & Allan Bank Centre for Clinical Research Trials (CCRT) works with Baycrest physicians, healthcare providers, and scientists at the Rotman Research Institute to offer a wide range of emerging interventions for older adults with various levels and forms of memory loss. Research participants play a major role in the development of emerging treatments and the advancement of our knowledge of Alzheimer's disease and related dementias. Yet, approximately 99 per cent of eligible patients are never referred to or consider participating in an AD clinical trial. At the CCRT, we have been able to overcome the barriers to participation and include as many people as possible in clinical trials. A variety of interventions are offered through the CCRT, including but not limited to: • Drug therapies • Dietary advice • Intense cognitive training and exercise • Non-invasive and safe electrical brain stimulation • Meditation • Light therapy • Other non-pharmacological approaches to boost brain function The CCRT team is currently involved in over 16 trials to treat and prevent dementia, which is more than any other centre in Canada. Among others, the team is trialing interventions from Eli Lilly, Alector, Biogen, Roche, and IntelGenX. The CCRT was one of the participating Canadian sites in the recent Lilly international Phase 3 study of Donanemab, an AD medication. This study led to the recent release of Donanemab in the USA (not yet in Canada). This represents a small but important advance in treatment to stop the progression of dementia. All studies offered through the CCRT are first reviewed and approved by the Baycrest Research Ethics Board to ensure that they meet current ethical standards. Through our partnership with Baycrest staff, local family doctors and specialists, and the Alzheimer Society of Canada, the CCRT welcomes members of the public to collaborate on studies that provide hope and potential solutions to individuals living with Alzheimer's disease and other dementias and their loved ones. Contact us If you are interested in participating in our clinical research trials, please contact our team to schedule an assessment of your eligibility. p: 416-785-2500 ext. 3627 e: navvaru@research.baycrest.org w: baycrest.org/clinicaltrials Anne & Allan Bank Centre for Clinical Research Trials Clinical trials are an essential step in developing effective treatments for Alzheimer's disease (AD) and related dementias. These research studies are designed to help test health treatments, including drugs, devices, lifestyle interventions, and other therapies, to evaluate their safety and effectiveness. Clinical trials provide many participants with access to cutting-edge treatments and expert medical care. With the Rotman Research Institute's focus on predictive neuroscience for precision aging, we want to predict which individuals will benefit the most from specific treatments, thus optimizing treatment outcomes. 22 BAYCREST ACADEMY FOR RESEARCH AND EDUCATION Dr. Howard Chertkow, Director, Anne & Allan Bank Centre for Clinical Research Trials

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