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15 BAYCREST | 2024 Promising interventions: Neuromodulation The new Bresver Neuromodulation & Therapeutics Program at Baycrest focuses on validating and optimizing novel brain intervention models. Non-invasive neuromodulation of the brain is one of the most promising treatment strategies for neurological and neuropsychiatric disorders. It is increasingly being studied for the treatment of Alzheimer's disease. Our scientists are currently working on a number of projects to find the best doses, location, intensities, and delivery system that will generate best outcomes in patients with various neurodegenerative diseases of the brain: • Transcranial Direct (and Alternating) Current Stimulation – a non-invasive form of brain stimulation that circulates a very low-intensity current through the skull. • Transcranial Magnetic Stimulation (TMS) – an electromagnetic coil which uses magnetic fields to stimulate nerve cells in the brain. • Photobiomodulation (PBM) – involves the use of near-infrared light to stimulate cellular function and promote healing; also known as low-level laser therapy or light therapy. These trials in the Bresver Program have the exciting potential of validating and optimizing breakthrough therapies, bringing science-based and Health Canada- approved brain stimulation devices and therapy clinics into hospitals, doctors' offices and people's homes. Imagine in the not-too-distant future, we could be propelled into a reality where prevention strategies and new treatments help aging Canadians defy dementia and keep our brain vitality strong for many more years!

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